Calluses on the feet can be treated with general therapy as well as medication. The existence of foot bone deformity, and more serious, but also need to carry out surgical treatment. 1. General treatment: the causative factors should be removed, choose the right shoes, and the soles should not be too hard, avoid excessive exercise for a long time, and don’t make the affected skin suffer from repeated friction. 2. Medication: Urea ointment, salicylic acid ointment, vitamin A cream, etc. can moisturize and exfoliate the skin surface. 3. Surgical treatment: calluses on the soles of the feet are caused by deformities of the foot bones, and the deformities are more serious, surgical treatment should also be considered, such as metatarsal bone and callus excision. In the treatment must listen to the doctor’s guidance, the rational application of drug therapy, do not indiscriminate use of drugs.