Headache and sore throat are seen in upper respiratory tract infection, acute pharyngitis, acute purulent tonsillitis and other diseases. Oral analgesic and anti-inflammatory drugs, anti-infective drugs, anti-virus and other drugs can be taken. 1. Upper respiratory tract infection: ibuprofen, acetaminophen, etc. to relieve symptoms, combined with ribavirin, oseltamivir, transfer factor and other antiviral drugs. If secondary bacterial infections, oral drugs such as amoxicillin, cefuroxime, azithromycin, erythromycin, levofloxacin and other drugs to control the infection. 2. Acute pharyngitis: acute inflammation of the pharyngeal mucosa, submucosal tissue and lymphatic tissue. Pharyngeal pain is obvious, can be radiated to the ear, severe cases have fever. Headache, lack of appetite and other discomforts. Selected antiviral and antibiotic treatment, such as four seasons antiviral, amoxicillin clavulanate potassium, cefuroxime, roxithromycin and other drugs. Compound borax solution gargling, iodine tablets, silver and yellow tablets containing chemical treatment. 3. Acute purulent tonsillitis: sore throat is obvious, accompanied by chills, fever, headache, loss of appetite and other discomforts. Preferred penicillin class, such as amoxicillin clavulanate potassium, according to the severity of the disease to determine the route of administration. Treatment for 2-3 days without improvement, analyze the reasons for changing to other classes of antibiotics, such as cefuroxime, azithromycin, etc.; antibiotics can be selected according to drug sensitivity tests, and glucocorticosteroids, such as prednisone, can be applied as appropriate. Drugs must be applied under the guidance of a doctor. If the symptoms of headache and sore throat occur, it is recommended that the patient timely hospital consultation, diagnosis and clear treatment.