Anti-hypertensive drugs are an important therapeutic measure in the treatment of hypertension, drug therapy for hypertension should generally adhere to the following principles: antihypertensive should not be too fast, should be gradually lowered; the choice of drugs should vary from person to person; the first treatment should start with a single drug, step up the drug (with the exception of severe hypertension); the combination of drugs is better than the effect of high-dose monotherapy; the amount of drugs must be used in accordance with the prescribed dose; can not suddenly stop the drug or suddenly stop a The drug; mastery and adherence to several drugs, new drugs may not be the best; choose not to affect the mood and thoughts of the drug; most patients must continue treatment consistently, unless it is necessary to change the treatment plan. The following principles can be used for reference in the selection of medications: 1, age 60 years or older, diuretics and calcium antagonists are usually more effective than beta-blockers, should avoid the use of reserpine or drugs acting in the center to prevent depression. To prevent postural hypotension, prazosin and guanethidine should be used with caution. 2, beta-blockers are appropriate for young patients, but this may limit the amount of exercise for some people. 3.People who have a history of stroke or mini-stroke should avoid drugs that can produce postural hypotension. 4.People with a history of depression should avoid the use of reserpine and its preparations. Centrally acting drugs such as methyldopa, colistin and beta-blockers can also cause or aggravate depression, so declare the use of angiotensin-converting enzyme inhibitors, diuretics, vasodilators, calcium antagonists and alpha-blockers, etc. 5. For patients with migraine, beta-blockers or calcium antagonists are appropriate. In some other specific cases of hypertensive patients, such as hypertension combined with diabetes, coronary heart disease, renal insufficiency, cardiac insufficiency, arrhythmia, hyperlipidemia, sexual insufficiency, asthma, gout and peripheral vascular disease, the selection of drugs must consider the advantages and disadvantages of drugs on the comorbidities. The cause of hypertension is not due to a single factor, so treatment should also be comprehensive, also called holistic treatment, including various means of drug therapy and non-drug therapy, in order to be the most ideal treatment for hypertension. Over-reliance on antihypertensive drugs, especially western antihypertensive drugs, is a wrong tendency in clinical practice. Any antihypertensive drug has side effects of varying degrees, and pharmacotherapy is not the ideal treatment. The use of antihypertensive drugs is only considered when non-pharmacological treatment is ineffective. For patients who must use antihypertensive drugs to explore blood pressure, holistic treatment (non-pharmacological treatment and the combination of Chinese and Western drugs) achieves better results and can reduce the dose and side effects of Western antihypertensive drugs. If the treatment is based on the stage or classification of hypertension, the principle of drug selection should be considered as follows: mild and moderate hypertension can usually be controlled with a single drug, such as diuretics, beta-blockers, angiotensin-converting enzyme inhibitors or calcium antagonists; severe hypertension requires a combination or stronger antihypertensive drugs to control blood pressure. The first stage of hypertension, blood pressure fluctuations, the use of non-drug therapy or Chinese medicine, Chinese herbal treatment can be, not necessarily with Western medicine to lower blood pressure; second stage of hypertension, blood pressure is often persistently and steadily rising, should be divided into light, medium and heavy blood pressure height, according to the mildness of the disease to choose antihypertensive drugs and Chinese medicine, Chinese herbal medicine; third stage of hypertension because of organ failure, so lowering blood pressure can not be too fast too low, in order to avoid aggravating organ failure. In order not to aggravate organ failure, the combination of drugs or the use of strong antihypertensive drugs should be very cautious, plus the use of evidence-based treatment of Chinese medicine is very meaningful.