The manifestations of prolonged sleeplessness are as follows: firstly, the patient develops mental abnormality, which is manifested as emotional anxiety, depression and so on. Secondly, with the prolongation of time will appear digestive symptoms, such as gastritis, gastric ulcer, etc.. Then, due to a long period of time without sleep, the patient has panic attacks, palpitations and other premature cardiac manifestations, and the prolongation of the duration of malignant arrhythmia, ventricular fibrillation, and so on, which can be life-threatening in serious cases. Prolonged sleeplessness, it is recommended that patients consult the hospital if necessary, oral drugs to promote sleep, take Chinese acupuncture, massage or herbal tonics to regulate, oral clearing the brain and rejuvenate the spirit of liquid, tranquilize the spirit and replenish the brain oral solution and other proprietary Chinese medicines, oral drugs such as dexrazopipecolone, but there are addictive, it is recommended that patients take orally under the direction of the physician.