Symptoms of diarrhea after taking azithromycin may be due to an adverse drug reaction, and interventions such as discontinuation of the medication need to be selected based on the specific condition. Several clinical reports have shown that azithromycin is prone to gastrointestinal adverse reactions, including nausea, vomiting, diarrhea, loose stools, and abdominal pain. This may be related to the drug’s ability to inhibit the activity of gastrointestinal flora and affect gastrointestinal function. For those with severe intolerable diarrhea, intervention can be made by discontinuing the drug or replacing it with another similar antimicrobial drug, such as erythromycin, and the symptoms can usually be relieved after discontinuing the drug. If the symptoms of diarrhea continue to be unrelieved, it is necessary to clarify whether there is a primary disease of the digestive tract, such as gastroenteritis, etc. If it is indeed caused by adverse drug reactions, can be given to those who have persistent diarrhea, such as montelukast and other antidiarrheal drugs, as well as bifidobacteria bifidobacteria tablets and other medications to improve the gastrointestinal tract bacterial flora to carry on the symptomatic treatment. For symptoms such as diarrhea, vomiting, abdominal pain, etc., it is recommended to go to the hospital in time.