The choice of antihypertensive drugs for 50-year-old hypertensive patients needs to be based on whether or not the combination of renal dysfunction, angina pectoris and other diseases, the choice of appropriate antihypertensive drugs such as the combination of renal insufficiency is preferred to Irbesartan and so on. 1. Hypertension: If the patient does not have other cardiovascular diseases, 50-year-old hypertension recommended amlodipine tablets, irbesartan, enalapril and other drugs, these drugs can be used as long-term maintenance therapy for hypertensive patients. 2. Combined with renal insufficiency: Irbesartan, Enalapril and other drugs are recommended to avoid aggravating renal dysfunction. 3. Combined with angina pectoris: patients with hypertension combined with angina pectoris are recommended to prefer beta-blocker antihypertensive drugs such as metoprolol, which can slow down the heart rate and reduce myocardial oxygen consumption while lowering the blood pressure. 4. Combined atherosclerosis: recommend preferred drugs such as enalapril and irbesartan, because these two drugs can inhibit blood vessel wall and cardiomyocyte remodeling at the same time as controlling blood pressure, which can protect cardiomyocytes. The emergence of hypertension, it is recommended to go to the regular hospital in time, according to the judgment and advice of professional doctors, choose the appropriate drugs.