Plantar blood is collected to screen for newborns at risk for neonatal diseases and deafness genes in order to achieve early detection and diagnosis and minimize the incidence of disability. Currently many genetic metabolic diseases can be completely restored to normal for babies after early detection in screening and early treatment through diet or medication. For example, congenital hypothyroidism and phenylketonuria can be improved by giving oral medications and a special diet. Early medication and life guidance for children at high risk for deafness genes can completely prevent the occurrence of deafness, so parents must pay attention to early pediatric blood screening to avoid causing lifelong regrets to burden the family and society.