When patients have chronic appendicitis, it is more appropriate to take antibiotic drugs, such as cefradine and metronidazole, etc. Surgery is usually recommended for patients with chronic appendicitis. Chronic appendicitis can choose effective antibiotic treatment, through the inhibition of intestinal aerobic and anaerobic flora, to achieve the purpose of antibacterial treatment. Clinical cephalosporin antibiotic drugs, such as cefradine, cefaclor, ceftriaxone and so on. At the same time with nitroimidazole antibiotics, such as metronidazole and other joint treatment. Generally found with chronic appendicitis, appendectomy should be carried out as soon as possible, while using drugs for anti-infection treatment. The above medications are for reference only, and patients are advised to seek timely medical attention and follow the doctor’s instructions to do the appropriate treatment.