Persistent low mood, loss of interest in life, insomnia …… If Parkinson’s patients experience the above symptoms, please be alert, you may be targeted by depression! ”In addition to typical motor symptoms such as tremor, motor slowing and limb stiffness, Parkinson’s disease patients are often accompanied by some non-motor symptoms, such as loss of smell, constipation, mood changes and sleep disturbances.” One of the common non-motor symptoms is depression, which can be comorbid in more than half of Parkinson’s disease patients. Although the prevalence of depression in Parkinson’s disease is high, only 20-25% of patients are treated. Parkinson’s disease depression needs more attention from doctors and patients. The effects of depression on patients with Parkinson’s disease can be divided into three main points: 1. It may accelerate the progression of motor symptoms in Parkinson’s disease; 2. It affects the patient’s ability to perform daily activities and reduces the quality of life; 3. It increases the burden on caregivers. Patients with Parkinson’s disease need to be alert to the occurrence of depression if they have the following manifestations: 1. depressed mood; 2. loss of interest in work and life; 3. significant weight loss or gain; 4. sleep disturbance; 5. fatigue; 6. guilt; 7. poor concentration. Depression is one of the common non-motor symptoms of Parkinson’s disease, yet it is not given enough attention by patients and families in real life. Reminder, if you have the above symptoms and suspect that you are suffering from Parkinson’s disease depression, please go to the neurology or psychology department of a regular hospital and consult a professional doctor to get timely diagnosis and treatment.