Chronic sinusitis only consider the use of antibiotics when there is an acute attack or a combination of bacterial infection, and the length of use should be controlled within two weeks, the recommended use of the general penicillin, second generation cephalosporin antibiotics or macrolide antibiotics. Need to be in the ear, nose and throat doctor’s guidance under the guidance of a reasonable choice of therapeutic drugs. Chronic sinusitis is the existence of chronic persistent inflammatory lesions in the nose and sinuses caused by a disease, its pathogenesis is more complex, the general treatment choice of nasal rinsing, nasal spray hormones and mucus drainage agent can be. Antibiotics are a class of drugs with antibacterial effect, is not a conventional drug for the treatment of chronic sinusitis, only in the acute attack of chronic sinusitis or a combination of bacterial infections can play a good therapeutic effect, commonly used antibiotics by macrolides such as roxithromycin, penicillin such as amoxicillin clavulanate potassium, cephalosporins such as cefixime, etc., but there is a history of allergic reaction to the relevant drugs is prohibited. Chronic sinusitis itself is more complex, each patient’s condition will have significant variability, the treatment used will be very different, so patients need to cooperate with the physician for individualized treatment, rational choice of therapeutic drugs, can not abuse antibiotics.