Sore and cold ankles can be caused by arteriosclerosis of the lower limbs, osteoarthritis, rheumatoid arthritis and so on. 1. Arteriosclerosis of the lower limbs: It may be due to insufficient blood supply to the blood vessels of the lower limbs caused by arteriosclerosis of the lower limbs, and the patient will have soreness, coldness and numbness around the ankle joints. 2. Osteoarthritis: Sore and cold ankles may be caused by osteoarthritis of the ankle joints. When osteoarthritis develops to the middle or late stage, patients may experience pain in the ankle joints due to arthritis that stimulates vasoconstriction of the synovial membrane. At the same time, poor blood circulation in the ankle joints will lead to symptoms of cold ankles. 3. Rheumatoid arthritis: Rheumatoid arthritis, which may be caused by infection, cold, dampness and other reasons, will have the clinical manifestation of cold and pain in the ankle joints, accompanied by joint swelling and limitation of activities, usually with bilateral symmetrical onset, and the onset of the disease is relatively acute. Ankle pain and coldness may also have other reasons, it is recommended to go to the regular hospital in time, complete the relevant examination, clear the cause of the disease, under the guidance of the doctor for targeted treatment or treatment.