Mucus with blood on the stool may be ulcerative colitis, bacillary dysentery, colon cancer and other disease factors, need to be targeted treatment under the guidance of a doctor, drug therapy with lumefantrine, levofloxacin, etc., and if necessary, also need to carry out surgical treatment. 1. Ulcerative colitis: Liuzasulfapyridine is suitable for the treatment of mild to moderate active patients, budesonide, prednisone and other glucocorticosteroids can control the active phase of the disease, if the glucocorticosteroids are not good treatment can be used cyclosporine, methotrexate and other drugs. 2. Bacterial dysentery: antibiotics such as levofloxacin and ciprofloxacin can be used to treat the disease. When accompanied by vomiting and diarrhea that lead to dehydration, rehydration therapy is needed, and attention should be paid to bed rest and isolation of gastrointestinal tract. 3. Colon cancer: chemotherapeutic drugs such as capecitabine and oxaliplatin can be used, targeted drugs such as cetuximab can be used, and surgical resection and radiotherapy should be considered. Patients with blood on mucus on stool are recommended to go to the hospital immediately, ask the doctor to make judgment, clarify the cause of the disease, and treat for the cause of the disease.