Creatinine 500μmol / L more, the patient may appear severe loss of appetite, nausea and vomiting symptoms, at the same time the patient may also be accompanied by heart failure, hyperkalemia, acidosis, etc., can lead to sudden death. Creatinine is an indicator of kidney function, and elevated creatinine suggests kidney failure. If creatinine has risen to more than 500 μmol/L, kidney function has been very poor, close to uremia. Such a high level of toxin will lead to the patient’s digestive symptoms are heavier, see everything have no appetite. This patient will usually have heart failure and will have severe chest tightness, breath holding, and possibly hyperkalemia and acidosis. Hyperkalemia and acidosis can cause malignant arrhythmias that can lead to sudden death in the patient. Patients with all this need to be given detoxification, control of blood pressure, correction of heart failure, hyperkalemia, and acidosis, and hemodialysis if necessary.