Duodenal ulcer may be self-healing, but the possibility of self-healing is relatively small. Duodenal ulcer is an inflammatory defect in the mucous membrane of the duodenum, if the patient’s condition is relatively mild and physically fit, change the bad dietary habits, and pay attention to the care of a certain degree of self-healing possibilities. However, most patients tend to experience recurrent discomfort, such as loss of appetite, nausea, vomiting, etc., and if the damage is more severe, it is often not self-healing. Duodenal ulcer if there is no Helicobacter pylori infection, mainly take acid-suppressing drugs and gastric mucosal protectants, such as omeprazole, lansoprazole and magnesium aluminum carbonate, aluminum hydroxide and so on. If H. pylori infection exists, regular quadruple therapy is required, i.e., a proton pump inhibitor, a bismuth agent and two antibiotic drugs, such as omeprazole, bismuth pectin, amoxicillin and metronidazole. Duodenal ulcers should be seen promptly, treated with medication in conjunction with the doctor, and reviewed regularly in the hospital.