The serious manifestations of septic osteomyelitis can be divided into systemic symptoms (high fever, chills, etc.) and local symptoms (swelling, pus flow, pressure pain, etc.). 1. Systemic symptoms: acute onset, severe systemic inflammation, obvious toxic symptoms, manifested as high fever, chills, body temperature above 39.0 degrees Celsius, obvious systemic sepsis, routine blood tests, leukocyte count and percentage of neutrophils increased significantly, C-reactive protein increased. 2. Local manifestations: local severe pain, elevated skin temperature, obvious pressure pain in the affected area, there may be edema, after the formation of abscess, there is pain can be alleviated, but the abscess spreads to the deeper tissues, to the bone marrow cavity infiltration, bone destruction, there may also be pus, pain intensification, the spread of the entire backbone can lead to pathologic fracture, it is very difficult to treat. Septic osteomyelitis develops rapidly, and it is recommended that patients actively seek medical treatment to avoid delaying their condition.