The difference between dry syndrome and SLE mainly lies in clinical symptoms and laboratory tests. 1. Clinical symptoms: SLE is a connective tissue disease with immuno-inflammation as its prominent manifestation, which can invade multiple organs and systems, so the clinical symptoms are more complicated, with common symptoms such as rash, alopecia, fever, and joint pain, etc. Desiccation syndrome mainly invades exocrine glands of the human body and leads to dry mouth, dry eyes, enlarged parotid glands, and caries, etc. The main signs of SLE are anti-SSA antibody and anti-SSB antibody, whereas SDS and SLS are mainly in the aspects of clinical symptoms and laboratory tests. 2. Laboratory tests: the signature antibodies of dry syndrome are anti-SSA antibody and anti-SSB antibody, while the signature antibodies of SLE are anti-nuclear antibody spectrum, anti-phospholipid antibody, anti-double-stranded DNA antibody, anti-Sm antibody, etc. The antibodies of dry syndrome and SLE are mainly against exocrine glands and lead to dry mouth, dry eyes, enlarged parotid glands and caries. Patients with dry syndrome and SLE are recommended to go to the rheumatology and immunology department of regular hospitals for detailed consultation and standardized treatment according to the doctor’s prescription.