Chromosome trisomy 22 can be caused by genetic factors, abnormal embryo differentiation, use of teratogenic drugs, radiation stimulation, etc. Of course, sometimes this is only occasional. Chromosome 22 trisomy may be caused by genetic factors or abnormal chromosome differentiation during the early differentiation of the embryo after the sperm and egg unite to form an embryo. Trisomy 22 may also occur when a male or female in the family has a chromosome 22 abnormality, or when there is a family history of the abnormality. In addition, the use of drugs that may cause fetal malformations or exposure to highly radioactive substances during pregnancy may cause abnormal differentiation of the embryo and the development of trisomy 22. For the sake of eugenics, one should actively prepare for pregnancy, avoid the influence of drugs or radiation, and after pregnancy, one should attend the maternity checkups on time, so that abnormalities can be detected and dealt with in a timely manner.