Vomiting at night may be caused by improper diet, late night, peptic ulcer and roundworm infection. 1. Improper diet: If the patient has the bad habit of overeating or eating a lot of greasy, cold and other stimulating foods at night, drinking alcohol at night can also stimulate the mucous membrane of the gastrointestinal tract, resulting in significant discomfort, manifested as vomiting and other symptoms. Generally, it can be self-healing. 2. Staying up late: staying up late for a long time can lead to elevated sympathetic excitability, which in turn causes autonomic dysfunction. May make the gastrointestinal tract hyperperistalsis, thus causing vomiting. It can also manifest as vertigo, palpitations and so on. 3. Peptic ulcer: duodenal ulcer can be manifested as increased discomfort in the fasting state, usually obvious abdominal pain, can also be accompanied by acid reflux, nausea and vomiting and other discomfort. Gastroscopy can be clear. Usually, acid-suppressing drugs such as omeprazole can be used under doctor’s guidance, and gastrointestinal mucosal protective agents such as teprenone can be added. 4. Roundworm infection: Roundworms are usually active at night. If the intestinal tract is infected with roundworms, at night, the frequent activity of roundworms in the intestinal tract can stimulate spasm of the digestive tract, which often causes severe abdominal pain and can also cause vomiting. Patients who vomit at night should go to the hospital in time to find out the cause and receive professional doctor’s treatment.