Sudden crooked face and mouth can be seen in acute cerebral infarction, but also can be seen in peripheral facial neuritis. The patient should consult a doctor in time, after clarifying the cause of the disease, symptomatic and causative treatment, and follow the doctor’s prescription of medication. Acute cerebral infarction is caused by local ischemia of brain tissue, resulting in impaired nerve function. If the center controlling the facial nerve is damaged, it can cause sudden crooked face and crooked mouth, and the patient should seek medical treatment in time and complete the examination such as cranial nuclear magnetic examination. If within 4.5 hours, thrombolysis such as alteplase should be actively used. If the optimal thrombolytic period is exceeded, oral aspirin, clopidogrel, atorvastatin calcium tablets and other symptomatic treatment. Peripheral facial neuritis can also cause sudden crooked face and mouth, can not frown symptoms, should consult a doctor in time, a clear diagnosis, the treatment is mainly drug therapy, such as the use of acyclovir, glucocorticoids, methylcobalamin, etc., can also be combined with acupuncture treatment. Suddenly crooked face and mouth may also be caused by other diseases, patients should go to the hospital in time, under the guidance of the doctor for treatment. All medications should be used as prescribed by the doctor.