The exact cause of anti-sperm antibodies in women is not very clear, and it is considered to be related to the immune response of women caused by sperm. When a woman has gynecological inflammation such as vaginitis, cervicitis, endometritis, etc., if she has sex at this time, the sperm, as an abnormal substance, will stimulate the woman’s immune system to produce anti-sperm antibodies after coming into contact with the bloodstream, and the persistence of anti-sperm antibodies will lead to female infertility. In addition, for women who have sex during menstruation, due to the obvious congestion of the vagina, cervix and other tissues at this time, the permeability of blood vessels increases, and sperm entering the vagina may also enter the female bloodstream to cause an immune response, resulting in the production of anti-sperm antibodies. For women who are found to have anti-sperm antibodies, it is recommended that they go to the gynecology or reproduction departments of regular hospitals for consultation and active treatment under the guidance of doctors to avoid affecting pregnancy.