Morpholine generally refers to domperidone, and esophageal reflux generally refers to gastroesophageal reflux, while domperidone and bismuth pectin can be taken together to treat gastroesophageal reflux, but the patient needs to comply with the doctor’s instructions for drug treatment. Gastroesophageal reflux is usually due to impaired anti-reflux structure and function, reduced esophageal clearance, reduced resistance of the esophageal mucosa, etc. It is also related to mental and psychological factors. Usually patients with mild symptoms and intermittent episodes can be treated with mucosal protective agents such as colloidal bismuth pectin as prescribed by the doctor, while domperidone belongs to the gastric stimulant drugs, which can be used in patients with gastric emptying disorder. Therefore, domperidone and colloidal bismuth together can be used for the treatment of gastroesophageal reflux, patients also need to follow the doctor’s advice to use cimetidine, ranitidine and other Hâ‚‚-receptor antagonists or rabeprazole, lansoprazole and other proton pump inhibitors to carry out the treatment, so that a better therapeutic effect can be achieved. It is recommended that patients with GERD should take medication strictly under the guidance of a doctor, and that they should know about Domperidone and Bismuth Pectin before taking them.