Closed pimples are actually a type of acne vulgaris. The reason for its formation is mainly due to the closed acne itself the opening belongs to the keratinization, or blocked pores, so that sebum can not be timely discharged from the skin surface, stagnation within the conduit, thus forming a certain amount of sebum embolism, and ultimately the formation of this closed acne. Its excretion is mainly affected by the body’s androgens, androgens stimulate the sebaceous glands after the sebaceous glands are induced to secrete a large amount of sebum, these sebum can not be excreted out of the surface of the skin, it may form the appearance of closed acne. Therefore, for closed acne, active treatment with keratin softeners is needed, especially with topical application of adapalene gel.