There are many causes of liver enlargement, the main ones are as follows: First, viral hepatitis, hepatitis B is the most common, if there is liver enlargement, pain and discomfort in the liver area, or elevated aminotransferases and high viral counts, it is necessary to take hepatoprotecting drugs as well as antiviral medications to standardize the treatment. Common hepatoprotective drugs include magnesium isoglycyrrhizinate, glycyrrhizinate diamine, reduced glutathione, etc. Antiviral drugs include entecavir, lamivudine, tenofovir, etc. Oral antiviral drugs should be continued for a long time, and the viral count should be rechecked once every three months, and the hepatoprotective drugs can be continued or discontinued according to the condition of liver function. Second, the liver itself, such as liver cysts, hepatic hemangioma, benign tumors can gradually increase with time causing liver enlargement, if not accompanied by other uncomfortable symptoms, you can follow up and observe, and review the ultrasound once every six months. If accompanied by pain in the liver area, compression of abdominal organs or large size, surgical treatment is recommended. Liver cysts can be treated with laparoscopic hepatic cyst opening and drainage, and hemangiomas can be treated with laparoscopic hepatic hemangioma resection or partial hepatectomy.