Among the gastrointestinal tract tumors, colorectal cancer should have better treatment outcomes, especially after the adoption of comprehensive treatment, with a significantly higher three-year survival rate. At present, consensus or progress has been made mainly in the following aspects: Colon and rectal cancers, despite their similarities, should be two different diseases in terms of disease treatment. Rectal cancer generally refers to cancer that occurs within 12 cm above the dentate line. In recent years, there is a tendency for the tumor to move upward, and the incidence of those below 5cm from the anal verge has decreased, mostly occurring between 5-9cm. Early detection and early treatment are the main ways to improve the overall treatment effect. Therefore, it is important to pay attention to early symptoms. Active preoperative treatment, the original treatment mode is to operate first, but it has been changed to advance some postoperative treatments to preoperative application depending on the disease: such as preoperative chemotherapy for colon cancer, preoperative radiotherapy for rectal cancer; preoperative treatment for liver metastasis, potentially resectable transformation treatment, etc. Timely postoperative follow-up can detect metastases early and take timely treatment to improve the prognosis. The application of targeted therapy has further improved the resection rate and long-term survival of primary foci and metastases. Active postoperative adjuvant chemotherapy can reduce the recurrence rate of tumor after resection. In recent years, intraperitoneal thermal perfusion chemotherapy has been carried out to reduce the rate of postoperative abdominal metastasis, which is better in China than abroad. Recent research proves that: different medical institutions or individuals have greater influence on the effect of tumor treatment, so patients are suggested to choose treatment institutions and experts carefully before treatment.