The medical name for vascular sclerosis is atherosclerotic occlusive disease. It is a systemic atherosclerotic lesion that occurs in the large and medium-sized arteries. It causes chronic ischemia of the lower extremities when it involves the abdominal aorta and its distal main arteries. Symptoms manifest differently in different stages of the disease. Stage I: The early stage of atherosclerotic occlusive disease only has symptoms of numbness and coldness in the diseased limb, lower skin temperature, paler color, and weakened dorsal foot artery pulsation. At this time, the diseased limb has limited arterial stenosis lesions. Stage II: Intermittent claudication occurs, and walking for 100 meters or hundreds of meters results in soreness and pain in the lower leg. Stage III: Resting pain occurs, and the pain persists even without moving the diseased limb. The pain is severe and persistent, and is worse at night. It may be accompanied by dark red toes and distal edema of the limb. At this point, the arterial stenosis is extensive and severe, and the tissue is on the verge of necrosis. Stage IV: At the end stage, symptoms continue to worsen, with blackening, drying, necrosis or ischemic ulceration of the fingertips. If secondary infection occurs, systemic symptoms such as fever, chills, and generalized muscle aches and pains may occur. Early diagnosis and treatment of the disease can improve the consequences, and the examination is relatively simple, and can be diagnosed by ultrasound, so if the above symptoms are found, early consultation should be made. Especially in patients with combined diabetes, hypertension and hyperlipidemia.