The main way to determine the red spots of syphilis is to observe the state of the skin lesions. Depending on the severity of the disease, syphilis can be categorized into Stage I and Stage II, and the state of the skin lesions also varies. 1. Stage 1: The skin damage of stage 1 syphilis is mainly hard chancre. In the early stage of the disease, the red spot of syphilis is a single red spot on the external genitalia or perianal area, but with the development of the disease, it will rapidly become a painless inflammatory papule, and then form a painless ulcer, with cartilaginous hardness to the touch. 2. Stage 2: the characteristic performance of red spots of stage 2 syphilis lacks certain specificity, usually patients with a type of skin damage disease, all over the body will appear, typical skin diseases include nodules, erythema, papules, papules plaques and so on. There is no obvious pain or itching. The rash is often symmetrically distributed when it appears in the palmoplantar area, accompanied by collar-like scales. When the patient’s skin appears uncomfortable symptoms, you need to go to the hospital in time for examination and diagnosis, after laboratory tests and syphilis serologic examination, as soon as possible to clarify the condition, and take positive intervention measures, to avoid delaying the aggravation of the symptoms of the disease caused by the serious impact.