It is difficult to return to normal when epilepsy occurs after craniotomy, and patients can control their symptoms with medication under the guidance of their doctor. Epilepsy after craniotomy is usually due to the damage of brain tissue and nerves during the surgery, causing abnormal discharges of neurons in the brain, which is difficult to return to normal. Patients can take medications such as carbamazepine, phenytoin sodium, valproic acid, and phenobarbital to control epilepsy symptoms. Due to individual differences, the drug does not exist absolute effective safety, need to strictly follow the doctor’s instructions standardized use, the emergence of adverse reactions should be timely consultation, drug allergy is prohibited. Epilepsy after craniotomy can be well controlled by drugs, but because the damage to the brain nerves is often irreversible damage, it is difficult to return to normal, and some of the early detection of patients may return to normal.