There are many reasons for IgE high eosinophils to be elevated at the same time, and the common causes are allergic diseases, infections, and so on. IgE is a kind of secretory immunoglobulin, which is produced by some inherent plasma cells such as tonsils or gastrointestinal mucosa, and it is the main antibody that causes type I allergic reaction. Eosinophils are a component of white blood cells and are extremely important in the process of immune and allergic reactions. IgE and eosinophils are elevated in the following conditions: 1. Metabolic diseases: in bronchial asthma and allergy, IgE will be elevated, and eosinophils will be activated by immune factors and released into the blood, which will also cause blood eosinophils to be elevated. 2. Infections: Parasites, roundworms, tuberculosis or other infections can cause high IgE and eosinophils. In addition, certain blood diseases such as chronic granulocytic leukemia and malignant tumors such as lung cancer can also lead to elevated eosinophils. When there is a prolonged period of high IgE and eosinophils, it is important to go to the hospital for relevant examinations to clarify the cause of the disease.