Herpes zoster is a disease caused by the varicella-zoster virus that affects the nerves and skin and can present as painful blisters distributed in clusters along the peripheral nerve course. It can be treated by oral medication and topical medication. 1. Oral medication (1) Antiviral drugs: Early and sufficient antiviral treatment is helpful to reduce neuralgia and shorten the course of the disease. Nucleoside antiviral drugs such as acyclovir and valacyclovir can be used. (2) Sedative and analgesic drugs: non-steroidal anti-inflammatory drugs (e.g., diclofenac sodium) and tricyclic antidepressants (e.g., amitriptyline) can be chosen for acute pain. Postherpetic neuralgia can choose to use gabapentin or pregabalin alone. (3) Glucocorticosteroids: Early and rational application of glucocorticosteroids such as prednisone can inhibit the inflammatory process and shorten the duration of acute herpes-related pain. (2) Topical drugs: antiviral drugs such as acyclovir cream or penciclovir cream can be used externally when the blisters are unbroken; antibiotics such as mupirocin ointment can be used externally after herpes breaks out. Shingles patients should seek medical treatment in a timely manner, under the guidance of the doctor to use medication, do not take medication without authorization.