Right shoulder pain can be ruled out as cancer by history, physical examination, CT, MRI and tumor markers. Right shoulder pain may be caused by joint strain, rheumatoid arthritis, trauma, and other common causes. Primary cancers or bone metastases such as lymphoma and osteosarcoma cannot be ruled out. Cancer can only be ruled out by a specific analysis based on the patient’s history, physical examination, CT, MRI and tumor markers. The nature of the pain in a cancer patient with right shoulder pain may be persistent, irregular, and difficult to relieve with rest or general analgesia. Many cancers with bone metastases can manifest as bone pain, and the pain occurs regardless of where the metastases have traveled. Cancer patients are often accompanied by physical examination abnormalities such as fever and enlarged lymph nodes. In addition, ancillary findings such as CT, MRI and tumor markers may be abnormal accordingly. It is recommended that patients with right shoulder pain and other suspected cancer symptoms should actively go to regular hospitals for definitive diagnosis in order to avoid delays.