Rheumatoid arthritis is a disease that cannot be completely cured at present, and Leflunomide is the most commonly used drug for rheumatoid arthritis. For rheumatoid arthritis patients, Leflunomide can be taken for a long time. However, the drug has some liver and kidney side effects as well as the side effect of leukocyte decline, so when applying Leflunomide, you should pay attention to monitor the liver and kidney function as well as the blood routine, and review once every 3 months. If liver and kidney function abnormalities and leukopenia occur, the drug should be discontinued and other medications should be adjusted. Therefore, patients with rheumatoid arthritis can take this drug for a long time, but should be regularly reviewed under the guidance of rheumatologists and dynamically observe the changes, and the application of this drug should try to avoid the influence of other factors such as alcohol consumption.