Nipple pain when touched may be caused by hormone level fluctuation, nipple trauma, breast hyperplasia, mastitis, mammary eczema-like carcinoma and so on, and it is recommended to consult a doctor in time. 1. Hormone level fluctuation: some women may experience nipple tenderness before menstruation and during early pregnancy due to changes in estrogen and progesterone levels. 2. Nipple trauma: such as abrasion, contusion, etc., can trigger significant nipple tenderness. 3. Mammary hyperplasia: it is a common benign breast lesion, patients often have breast pain, breast nodules or lumps, nipple overflow and other uncomfortable symptoms, some patients may be accompanied by nipple tenderness. 4. Mastitis: refers to inflammation of the breast tissue with or without infection. In addition to local symptoms such as nipple tenderness, localized lumps, breast pain, nipple inversion, nipple discharge, etc., patients may also suffer from systemic symptoms such as chills and high fever. 5. Mammary eczema-like cancer: it mainly manifests as itching and reddening of one side of the nipple, followed by erosion, which may be accompanied by nipple tenderness, and the lesion may gradually involve the areola skin and even cause lumps in the mammary gland. If the patient has the symptom of nipple pain when touching, and the symptom continues to be unrelieved or the symptom is more serious, he/she should consult a doctor in time, follow the doctor’s instruction to find out the cause of the disease, and follow the doctor’s instruction to carry out the corresponding treatment if necessary.