After nearly 200 years of development and refinement, triple oxygen therapy is now the treatment of choice or adjunct to certain metabolic, infectious, infectious, degenerative and autoimmune diseases. An increasing number of patients have benefited from trioxane therapy. Years of clinical application have confirmed that the side effects of trioxane clinical application are much lower than those of general clinical use.
I. History of trioxane medicine Wang Junyou, Department of Male Medicine, Jining City Hospital of Traditional Chinese Medicine Bu Xiaoyu, Department of Pain, Yang Yuan County People’s Hospital
The origin of trioxane and medicine has nearly 200 years of history. 1826 The function of trioxane to kill bacteria was written down. 1840 Schonbein discovered “active oxygen”. 1870 The first report of blood purification with trioxane was published in Europe. 1885 The first book detailing the medical use of “ozone” was published. 1902 The first successful treatment of anemia and diabetes with trioxide is described in the Manual of Medical Practice by J.H. Clarke. 1915 Dr. Wolff in Germany successfully treats skin diseases with trioxide. During World War I, German doctors used trioxide to treat a large number of open trauma and anaerobic bacterial infections. 1932 Fisch, a German dentist, introduced ozone as an anti-infective drug. In the same period, the French doctor Aubourg applied trioxane to rectal irrigation to treat colitis. 1935 Austrian Professor Erwin Pastor published a paper on “The use of trioxane in surgery”. 1945 Professor Payr pioneered the application of trioxane intravenously to treat circulatory dysfunction. 1958 German Joaquim Hansler invented a controlled concentration In 1966, Professor Otto Warburg was awarded the Nobel Prize for his research on the anaerobic nature of tumor cells. After that, scientists tried to treat cancer with high specific gravity of trioxane and achieved good results in clinical practice. In 1972, the first German association for oxygen-ozone therapy was organized, and in 1979, a book by Dr. H. Wolff (1927-1980) on the many uses of ozone in medicine was published. He was the first to start using a true medical triple oxygen generator. He developed Oxygen Trioxide Autologous Blood Therapy (O3-AHT).The International Conference on Ozone Therapy was held at the Glaxo-Wellcome Research Center in Verona from March 11-13, 1999. The opening ceremony commemorated the 200th anniversary of Schonbein’s birth. 2004 VELO BOCCI, Italy’s “Ozone Therapy” was launched.
Reviewing the brief history of the development of triple oxygen medicine makes us see that: triple oxygen has been very effective in the treatment of blood purification, treatment of anemia and diabetes, skin diseases, open trauma and anaerobic bacterial infections, genitourinary infections (prostatitis, pelvic inflammatory disease, cervicitis, vaginitis and urethritis, etc.), colitis, circulatory dysfunction and other diseases.
Second, the status of the clinical application of trioxane
The scope of application of triple oxygen in medical clinic is getting wider and wider. Now it is known that ozone can effectively reduce blood lipids and improve blood viscosity, and has good efficacy in the treatment of cardiovascular, cerebrovascular and peripheral vascular diseases. The European journal Artif Organs, No. 28, 2004: “The effect of triple-oxygen macroauto-hemodialyzed therapy on the maintenance of lipid profile and endothelium in hemodialysis patients” showed that in 12 patients with artificial kidneys [hemodialyzed] who received nine sessions of macroauto-hemodialyzed therapy with a triple-oxygen concentration of 50ug/ml, low-density lipoprotein (LDL) was significantly was significantly lower than the initial value, with a mean reduction of 17.7%, and total cholesterol was also significantly reduced by 8.34%. This study showed that triple-oxygen macroautohemotherapy had no deleterious effect on chronic renal failure patients maintained on hemodialysis; and when total cholesterol and LDL-cholesterol values were reduced, it stimulated a beneficial shift in serum lipid profile. This article reports on a study of cholesterol changes in 22 patients with a three-month to one-year history of myocardial infarction who received 5-15 triple-oxygen autologous blood transfusions. The results of their study were: After 5 sessions of trioxane macroautotransfusion, the 22 patients had an average decrease in cholesterol of about 5.5% and LDL of about 15.4%; after 15 sessions of trioxane macroautotransfusion, these patients had an average decrease in cholesterol of 9.7% and an average decrease in LDL of 19.8%. Their study also found that erythrocyte glutathione peroxidase and glucose-6-phosphate dehydrogenase activities were biologically significantly increased in 22 patients treated with trioxane macroauto-hematology. This study showed that the improvement of lipids in 22 infarction patients was correlated with the number of trioximetric macroautohemotherapy sessions. The efficacy of trioxane macroauto blood in the treatment of coronary artery disease, angina pectoris, myocarditis, arrhythmia, bradycardia and other cardiovascular diseases has also been reported in many foreign medical journals. Each time, 200 ml of venous blood was mixed with a concentration of 60µg/ml and a volume of 200 ml of ozone and then returned to the transfusion. Blood flow velocity and vessel diameter were then measured with a transcranial Doppler rate meter. These vascular rheological parameters as well as the treatment effect on the vasculature showed that this technique increases the oxygen content dissolved in the arterial blood and enhances the elasticity of the vessels. The treatment, when continued for 15-30 minutes, causes vasodilation of constricted vessels in most organs of the body and increased resistance of the peripheral vasculature. This study had a small number of subjects, but preliminary results showed that triple oxygen therapy increased the value of blood flow in the CCA and MCA and that the therapeutic effect lasted for a longer period of time. This suggests that triple oxygen therapy is an effective means of modifying peripheral ischemic complications and treating underlying cerebral hypoperfusion disorders. Relevant domestic studies have also confirmed that trioxane can activate cellular metabolism after entering the body, improve blood circulation, improve the ischemic and hypoxic condition of brain tissue, increase the oxygen content of brain cells, improve the symptoms of hypoxia such as dizziness and swelling in patients with cerebral infarction, and improve clinical symptoms and muscle strength of affected limbs and speech impairment. (Aphasia, dementia) The therapeutic effect observed in the above study appeared to be more prominent in older patients and patients with lower initial values of blood flow, suggesting that the therapy would be more effective in patients with complications of cerebral hypoperfusion and in patients with stroke. Transcranial Doppler (16) and magnetic echo (17) studies have also demonstrated the therapeutic effect of trioxane macroautotransfusion therapy on alterations in cerebral blood flow. These findings are further supported by the clinical experience gained in another study of 150 patients suffering from ischemic cerebrovascular disease treated with trioxane for a longer period of time (18). Many clinical studies have also confirmed that trioxane alters the way platelets aggregate in the blood, generates peroxides in the presence of thrombi to modify the development of thrombi, promotes the disintegration of thrombi, oxidizes and removes fatty substances such as chromatophores that adhere to the walls of blood vessels, and increases the elasticity of blood vessels. It regulates the permeability of blood vessels, promotes the healing of wounds, and reduces the occurrence of infections.
Trioxane therapy has a faster and more desirable therapeutic effect on headache, migraine, gout, rheumatoid rheumatic pain, diabetic foot pain, vasculitis pain, herniated disc pain, joint pain, periarthral pain, various inflammatory and infectious pain, and many unexplained pains. It can also significantly reduce cancer pain and discomfort, improve their mental state and sleep, and improve their quality of life for patients with advanced cancer. Trioxane is not only effective in pain relief and analgesia, but also has no side effects and addiction, and the therapeutic concentration is not toxic in any way. Trioxane can also react with stone uric acid and other abnormal mineralization through its super strong oxidative decomposition, change its solubility and promote its excretion from the body. It can also prevent the production of abnormal mineralized substances by improving the immune and metabolic functions of the body. Tri-oxygen also has ideal therapeutic effects on allergic rhinitis and acute warts. Ozone therapy not only has ideal therapeutic effect on skin septic infection, burn infection, diabetic foot infection, vasculitis infection, foot fungus, nail fungus, bedsore, acne, eczema, herpes; acute and chronic enteritis, colitis, parasitic infection; gynecological urogenital system infection and other diseases, but also has fast effect without any side effects.
Foreign reports, triple ozone therapy on glaucoma, corneal ulcers, five pigment retinitis, optic nerve atrophy and diabetic retinitis has a certain therapeutic effect; one of the clinical studies using the large self-blood therapy on optic atrophy confirmed: three weeks after treatment visual acuity improved 54%, visual field improved 83%, visual acuity excitation potential improved 37%, although not all patients can be cured after using ozone therapy Although not all patients can be cured after ozone treatment, it can significantly improve the symptoms and can be an effective supplement to other treatments.
A study of triple oxygen therapy on 12-finger ulcers reported from abroad found that 40% of patients were completely cured at the end of treatment, 10% were in the final stages of scar formation, 25% formed 50% of the scars, 5% formed 33% of the scars, and 20% discontinued treatment due to intense pain. The results of the clinical study showed that triple oxygen therapy had better efficacy in 12 finger ulcers. (Driver Zhang)
Foreign studies have confirmed that ozone has the same effect as insulin, accelerating glucose metabolism in the body, promoting sugar conversion and lowering the patient’s blood glucose concentration, while avoiding fat burning in patients.
For the treatment of burns, the use of triple oxygen macroautohemotherapy, sleeve therapy or triple oxygen water sedation therapy can significantly reduce the pain and discomfort of burn patients, improve mental status, promote sleep, increase the energy level of the body, significantly shorten the healing time of burns, and have obvious advantages compared with burn medication.
For the treatment of neurodermatitis, on January 14, 2001, the Vancouver Symposium on Triple Oxygen Therapy reported that after intestinal injection of triple oxygen or treatment with large autologous blood therapy, 75% of 68 patients who received treatment gave feedback with results of “good, very good” and 15% of patients were “satisfactory”; only 4 patients did not have any improvement in their condition.
According to foreign information reports and related books, triple oxygen therapy has certain therapeutic effects on osteoporosis, autoimmune deficiency diseases, decubitus ulcers, tumors and cancer. The German journal “Acozon–Information”, or “Trioxane Information Exchange”, published that Dr. Horst Kief, in his analysis of the results of 70 patients treated with ozone, stated: “The average time for trioxane therapy to begin to have a therapeutic effect on cholesterol reduction is about 15 days later “. “According to Dr. Horst Kief, “the therapeutic effect of macro-oxygen therapy is firstly a significant reduction of cholesterol in the blood. Dr. Kief also believes that the results and reactions to this therapy have been positive and that the effects have been very long-lasting in many cases, some of which have been observed continuously for two years.
In summary, the known indications for triple oxygen therapy cover almost all diseases from cardiovascular, cerebrovascular and peripheral vascular diseases, to renal diseases, digestive system diseases, hematological diseases, endocrine diseases, geriatric diseases, infectious diseases, parasitic diseases, venereal diseases, dermatological diseases, gynecological and urological diseases, ophthalmic diseases, burns, oncology, surgery, pain, orthopedics and many others.
Three, the five medical functions of trioxin
(A) Anti-inflammatory and anti-infection function
Trioxane can produce hydrogen peroxide by contacting body fluid. Trioxane (O3) and hydrogen peroxide (H2O2) are two strong oxidants, which will directly kill pathogens such as bacteria, viruses and parasites or diseased cells in the body once they enter the body and remove them. The killing rate of trioxide to Pseudomonas aeruginosa can reach more than 99.99%; the killing rate of trioxide to Staphylococcus aureus, Escherichia coli, Salmonella typhimurium, Bacillus fowleri and Vibrio cholerae can reach 100%. The killing rate of trioxide to Bacillus subtilis, black variant bacillus, under certain conditions can reach 99.99% The killing rate of trioxide to Trichoderma, cyanobacteria, Aspergillus niger, Candida albicans, etc. can reach 100%; 0.5ppm of trioxide can inactivate 99% of influenza A virus in the air; 0.13mg/L of trioxide can completely inactivate type I poliovirus; 4mg/L of trioxide can make drops 4mg/L of trioxane can inactivate all HIV titers of 106CID50/ml, and the titer of virus drops by 6 log values. The effect of trioxane for 30 minutes can reduce the titer of hepatitis B surface antigen by half, and the antigen of hepatitis A virus is destroyed by 100%. If the concentration of trioxane reaches a certain threshold, its disinfection and sterilization can be completed instantly. German medical expert Horst. Kief believes that the effect of ozone on microorganisms can be compared with formaldehyde solution. The special function of trioxane to kill bacteria, fungi and viruses had made an indelible contribution to human life and health during World War I and World War II, but by the middle of the 20th century, with the emergence of various antibiotic drugs, the clinical application of trioxane was gradually excluded from medical practice.
In recent years, due to the frequent mutation of pathogenic bacteria, drug resistance, anti-inflammatory new drugs, although constantly introduced, antibiotic dosage has also increased exponentially, but the therapeutic effect is not ideal; second, the increasing number of cases of mixed infections of a variety of pathogenic bacteria, in the face of a wide range of antibiotics, the treating physicians but often difficult to choose, even if the combination of drugs, the treatment effect is also mostly unsatisfactory; third, the side effects of antibiotics are large, causing many patients The medical safety is frequently alarmed, and medical disputes are often constant. Fourth, the price of new antibiotics is outrageously high, patients not only have to endure the suffering of the disease, the pain of drug side effects, but also carry a huge economic burden. In the face of many difficult problems, people can’t help but think of the natural antibiotics that have been forgotten for years – trioxane. When you face the pathogenic microorganism infection, because of bacterial resistance and difficult to choose antibiotics; when you face the pathogenic bacteria mixed infection, combined with the application of a variety of antibiotic treatment without the desired effect, please consider the first choice of trioxane treatment. Trioxane can kill bacteria, fungi and viruses quickly and completely, and it is a broad-spectrum antibiotic that does not produce resistance. The fact that trioxane therapy is better than antibiotics and challenges antibiotics has become a fact that clinical practitioners must face up to.
(II) The function of oxidized cholesterol
An article titled: “Evidence for the formation of trioxane in human atherosclerotic arteries” was published on page 1053 of the July 2003 issue of the American Journal of Science, No. 302. This article reported the discovery by British scientists that an oxide: 4b-2.4=nitrophenylhydrazone, or hydrazone 4b for short, was present in the carotid endarterectomes of 14 patients with atherosclerosis, a marker that is only present when cholesterol is broken down by the oxidation of trioxides, and that subsequent chemical structure analysis confirmed that ozone does indeed cause the Δ5.6 The chemical structure analysis later confirmed that ozone does break the Δ5.6 double bond of cholesterol. None of these patients were treated with exogenous trioxides at the time, and these trioxides were apparently self-generated in the patient’s organism. They suggest that this endogenous trioxane may have been produced by the immune system as a manifestation of the body’s defense function, but in insufficient amounts to contain plaque formation and progression. Accordingly, scientists believed that since trioxane could oxidize cholesterol, its use to lower blood lipids should certainly be effective as well. Later clinical practice confirmed the scientists’ speculation.
(iii) Pain-relieving and analgesic function
Trioxane can increase the activity of erythrocyte glutathione peroxidase and glucose 6-phosphate dehydrogenase, and enhance the lipid peroxidation reaction. Ozone can stimulate the release of enkephalins and other substances, and has a similar effect to chemical acupuncture. Trioxane can also oxidize and inactivate various pain-causing substances in the body. Since trioxane has the above three aspects of pain relief and analgesic functions, it has a better therapeutic effect whether treating headache, migraine pain, gout, rheumatoid rheumatic pain, inflammatory pain, or pain of unknown cause and cancer pain. The mechanism of stimulating and enhancing the immune system of the body may be that it can react with unsaturated fatty acids on the surface of immune cells to generate lipid peroxide chains, which can activate the nuclear factor NFKB when they enter the cells, thus activating the replication, transcription and translation of mRNA, promoting protein synthesis and cytokine release.
(D) Stimulate and enhance the immune function of the body
Trioxin can activate immune active cells, increase the release of cytokines such as interferon and interleukin, and enhance the immune function of the body. By the name of long-acting interferon. By acting instantly with the body, trioxane can increase the number of free radicals, induce and activate the body’s antioxidant enzyme system, cause the production of free radical scavengers such as superoxide dismutase, glutathione peroxidase and reductase in large quantities, and remove excessive free radicals from the body, thus regulating the body’s antioxidant capacity. Trioxane can promote the tricarboxylic acid cycle, promote the body’s use of sugar, enhance the release of energy, stimulate basal metabolism, limit protein and fat burning, and activate the normal metabolism of the body. Trioxane can oxidize and decompose the waste and toxic substances produced by the body’s metabolism, and oxidize and decompose the toxic substances produced by harmful bacteria and viruses, and promote the discharge of harmful substances on the basis of improving the body’s metabolic level.
(V) Improve the function of the body’s lack of oxygen
Trioxin can activate red blood cells, increase the level of adenosine triphosphate (ATP) and 2.3-diphosphoglycerol (2.3-DGP), increase the oxygen-carrying capacity of blood and promote the release of oxygen by red blood cells, and increase the oxygen supply to tissues. Trioxane also increases the deformability of red blood cells and improves blood rheology. Trioxane is easily soluble in water, so it can increase the content of dissolved oxygen in the blood and increase the partial pressure of oxygen, which are beneficial to the improvement of the hypoxic condition of the body tissues. After entering the cavity or carrying out the anti-inflammatory and anti-infection of the body surface, the ozone decaying and reducing to oxygen can also supply oxygen to the ulcer tissue and promote the recovery of the lesion.
Four, trioxane medical function basis
Trioxane is a strong oxidant second only to fluorine, which will have different effects on different compounds with different reaction mechanisms, and has obvious selectivity at different PH values. When PH ≤ 7.4, i.e. in the presence of unsaturated fatty acids in the physiological state, the 1.3 dipole of trioxane reacts with unsaturated fatty acids (e.g. phospholipids on cell membranes) to produce peroxides after breaking double bonds (especially with isolated double bonds). Thus, as far as physiological PH is concerned, its ionic reaction mechanism prevails and does not promote the formation of free radicals. As a catabolic product of ozone (in contrast to the auto-oxidation of fatty acids by atmospheric oxygen), hydroperoxides can enter the cell through the phospholipid gap of the cell membrane, thus affecting cellular metabolism, leading to an elevation of ATP and 2,3-DPG and to an increase in immunoreactive cells by activating the nuclear factor NFKB, producing an induction effect and eventually leading to the release of cytokines. In alkaline media with pH ≥ 8, trioxane can generate free radical reactions that increase the formation of hydroxyl radicals, which trigger free radical chain reactions. This explains, to some extent, how trioxane can have multiple medical functions. On the other hand, unlike oxygen, as soon as trioxane encounters tissue fluid, plasma, lymphatic fluid and urine, the following reactions immediately occur.
O3 + biomolecules -> O2 + O to produce oxygen molecules and oxygen atoms.
After the above reaction, the oxygen molecules no longer exist. O3 reacts preferentially with polyunsaturated fatty acids (PUFA), antioxidants (e.g. ascorbic acid, uric acid, thiol compounds), SH groups (e.g. cysteine, GSh (glutathione) and albumin). Different doses of ozone can also react with carbohydrates, enzymes, DNA, RNA. All of the above are reduction reactions in which electrons are lost. Main reaction formula.
R-CH=CH-R’+O3= H2O-> R-CH=O+ R’- CH=O+H2O2
One of the important ROS (reactive oxygen cluster) molecules – hydrogen peroxide is the intermediate product of trioxides also the primer for many biochemical reactions. ( 13,14 ). Nowadays the view that ROS substances are harmful has been revised and they are regulators of signaling and the body’s defense and immune response.
Hydrogen peroxide (H2O2) can catalyze most OH-root reactions.
Fe++ + H2O2 -> Fe+++ + OH+ + OH-
Foreign experts have detected NO in intracellular fluids containing trioxides, and it is worth noting that NOO-, CLO- and other toxic substances can be formed if ROS are exceeded. In addition, LOPS substances can produce many kinds of oxidative stress proteins, one of which is called (HO-1 or HSP-32) prohemoglobin, which destroys heme molecules and produces useful compounds such as CO and bilirubin (18). Bilirubin is an important fat-soluble antioxidant that promotes the binding of CO to NO and plays a regulatory role in the initiation of the GMP cycle in the organism. It rapidly generates many divalent iron ions in the presence of excess iron salts. The primer of HO-1 after oxidative stress is nowadays recognized in academia as an important antioxidant protective enzyme. During trioxane treatment, patients generally report feeling good due to the efficacy of the LOPS produced as an immunomodulator. Researchers hypothesize that LOP acts as an oxidative stress-sensitive substance during treatment to trigger the release of metalloproteinases in bone marrow cells, where MP-9, a metalloproteinase, promotes the division of tolerant cells. Once these cells enter the blood circulation they actively approach the trauma area and act as a healing agent.
The above principles can explain us why trioxane has five major medical functions, why receiving trioxane treatment will receive fast and effective treatment effect, and why the patients’ response will be generally good.
V. Safety of triple oxygen therapy
In 1980, the German medical community organized a retrospective study of 644 experts on triple oxygen therapy, they analyzed the results of 579238 treatments of 38475 patients, and found that only 40 people had side effects, the percentage was 0.000007%, some of which were indirectly caused by complications of other diseases, which shows that triple oxygen therapy is indeed the safest. This indicates that triple oxygen therapy is indeed the safest. Compared with the incidence of adverse reactions to other treatment techniques, the side effects of trioxane therapy are almost negligible.
In more than 100 years of clinical application of trioxane, there are only four documented cases of death, and the deaths were caused by gas embolism due to the implementation of intravenous trioxane injection, so the German health authorities and the European Union health agencies abandoned intravenous trioxane therapy, and the trioxane macroautohematology technology was born.
Sixth, the 12 techniques of triple oxygen therapy
Triple oxygen therapy (also known as ozone therapy) is the use of medical oxygen, water or oil as a carrier, the quantitative triple oxygen through oral, subcutaneous injection or rectal, vaginal infusion effect on the human body. It can be applied alone or in combination with conventional therapy.
The amount of trioxane used is generally 0.05%-5%, and in most cases, the ratio of applied trioxane to pure oxygen mixture components is 0.05 : 99.95, and there are also topical agents such as trioxane baths with a mixture ratio of 6:94. The exact dose depends on the individual case. Clinical studies have shown that doses need to be precisely quantified according to individual conditions, disease types, etc. Insufficient doses may not be effective, but too many doses can suppress the immune system.
In addition to the inhalation route, many non-intestinal and local routes are used in trioxane therapy. At present, more than ten types of triple oxygen therapy are used in clinical care abroad as follows
Systemic therapy
1 Large autologous blood therapy 50-150ml of venous blood is drawn and injected into a special sterile container with anticoagulant, and then a prepared triple oxygen mixture (triple oxygen concentration 5-30μg/ml, about 50-300ml) is injected into the container. The blood is slowly shaken and the contents of the container are gently mixed for 5 minutes, and then the blood is reinfused back into the patient’s vein. The amount of trioxane dissolved in the blood can be calculated by multiplying the volume of the gas being used by the concentration of trioxane. Typically, the course of treatment is 2-3 to 8-10 times.
2 Intravenous input of saline trioxide 200-400 ml of sterile saline is pre-treated with trioxide to a concentration of 1-6 μg/ml and then injected intravenously at a rate of 3-7 ml per minute. Because the trioxane in solution dissociates rapidly, the trioxane saline needs to be prepared immediately prior to administration to the patient. Initially the saline has a high concentration of trioxane, and to avoid phlebitis, the injection rate is slightly slower (up to 30-70 drops/minute) for the first 5-10 minutes and gradually accelerates thereafter.
3. Rectal blowing of triple oxygen mixture 50-500 ml of gas with a triple oxygen concentration of 5-40 μg/ml is injected into the rectum through a special device. The duration is 0.5 to 5-10 minutes. In order to carry out the above-mentioned treatment process, the intestinal tract should be purified beforehand. These treatments have a systemic effect on the patient’s organism and help to regulate all aspects of metabolic imbalance, alternating with intravenous saline or large autologous blood therapy. In addition, the triple oxygen mixture blow-in method has two simultaneous effects, namely a systemic effect and a local effect.
4 Small autologous blood therapy 5-15 ml of venous blood is drawn with a syringe containing 5-10 ml of trioxane mixture. After careful mixing, the tri-oxygenated blood is injected intramuscularly into the patient’s outer buttocks.
Topical therapy
1 Subcutaneous injection of trioxane mixture The gas is usually injected into the painful area or around the subcutaneous lesion area, or even around the large joints. The concentration of trioxane ranges from 1-2μg/ml to 10μg/ml. 2-3ml to 10-12ml of gas is injected in one area.
2 Intramuscular injection of triple oxygen mixture The concentration of triple oxygen for intramuscular injection therapy is 3-20 μg/ml, and the volume of triple oxygen mixture injected is 10-20 ml.
3 Intra-articular and peri-articular injection of triple oxygen mixture The concentration of triple oxygen in triple oxygen mixture is 5-18μg/ml The amount of triple oxygen injected into the joint cavity or around the joint depends on the number of joints and ranges from 1-3ml (small joints) to 15-20ml (large joints).
4 Intra-arterial and intravenous injection of triple oxygen mixture This method is the most common method, but has strict index limits and requires sufficient experience and careful attention.
5 Radiation therapy with trioxane Injection of 0.2-1.0 ml of gaseous trioxane at low concentrations (1-5 μg/ml) into the pinpoint. biologically speaking, it can act on 5-12 active sites at a time.
6 Saline or distilled water with trioxide is administered orally with trioxide or by washing or spraying with it. The liquid held in a special glass or plastic container is made to foam and reach the necessary concentration within 2-15 minutes. The rate of increase of trioxide and its ultimate level depends on the type of trioxide liquid, temperature and a series of other factors. Under otherwise identical conditions, the application of saline for trioxide takes a longer time and decomposes somewhat faster than distilled water. As the temperature of the liquid increases, the rate of decomposition of the trioxides dissolved in the water increases. The trioxidized liquid should be used within 10-40 minutes after preparation. Generally speaking, the concentration of trioxide in the liquid after trioxidation is 0.5-7 μg/ml.
7 External use of trioxane mixture When using trioxane mixture topically it must be remembered that the bactericidal effect of trioxane occurs only in a wet medium. High concentrations of trioxane have a hemostatic effect and low concentrations of trioxane improve microcirculation as well as facilitate the recovery of hemophiliac patients with surface injuries.
8 Trioxide oil is applied to the mucous membrane or skin with a thin sheet 1-2 to 4-6 times a day. It should be noted that if the inflammatory reaction of the injured area is severe, then it is necessary to dilute the trioxide oil with ordinary petroleum jelly in a ratio of 1 : 1 to 1 : 3 at the beginning of the treatment.
9 Normal pressure or low-pressure hood use For example, using the “triple oxygen boot”, wet the limb end with distilled water or saline before treatment, and seal the limb end with a thin sheet hood. The hood is filled with a triple oxygen mixture and the excess gas enters the decomposition unit of the triple oxygen therapy device. The treatment time is 15-30 minutes. When there is no damage to the skin surface, the concentration of trioxane is 8-10 to 25-30 μg/ml. when there is fresh granulation on the wound surface, the concentration of trioxane is reduced to 2-5 μg/ml. after the maximum treatment time is reached, oxygen is blown into the lamellar hood for 5-10 minutes before the hood is removed from the limb end.
After entering the body, trioxane or its innate hydrogen peroxide directly or indirectly becomes the nemesis of viruses, bacteria, molds, microorganisms, diseases and weakened tissue cells, etc. By oxidation, these disease-causing microorganisms are destroyed and expelled from the body, and the immune function of the body is enhanced. Therefore, it is widely used to treat many diseases such as internal, external, maternal and child, and oral diseases.
Diseases treated
1. surgery, such as: burns, scalds, diabetic ulcers, chronic migratory wounds, radioactive dermatitis or ulcers and other wounds caused by various reasons.
2. skin diseases: e.g. acne, eczema, dermatitis, psoriasis, gangrene, herpes zoster.
3. cardiovascular diseases, such as: arterial embolism, atherosclerosis, Raynaud’s disease, cardiac arrhythmia, coronary artery disease, hypotension
4. respiratory diseases, such as: emphysema, asthma, bronchitis, chronic lung disease.
5. metabolic-immune diseases, such as: diabetes, allergic diseases, arthritis, beriberi, rheumatism, rheumatoid arthritis, ankylosing spondylitis, chronic degenerative diseases, hypersensitivity reactions, contact dermatitis, systemic lupus erythematosus, clonal diseases
6. infectious diseases, such as: diverticulitis, adenovirus infection, malaria, AIDS, encephalitis,, encephalomyelitis, endometritis, mumps, EBV infection, condyloma acuminata, gout, Candida infection, Salmonella infection, cellulitis, staphylococcal infection, cytomegalovirus infectious diseases, syphilis, dengue fever, pelvic inflammatory disease, prostatitis.
7. tumors, such as: malignant metachromatic tumors, leukemia, hairy leukemia, lymphoma, bone tumors, various types of tumors, also for radiotherapy sensitization, post-operative recovery, control of recurrence.
8. Other, such as: chronic pain, Alzheimer’s disease, Addison’s disease, migraine, amyotrophic lateral sclerosis mononucleosis, amenorrhea, multiple sclerosis, myalgia, food poisoning, Parkinson’s disease, glaucoma, prostate hyperplasia, paralysis, acute and severe diseases, tubal effusion, cirrhosis, colitis, liver failure, tinnitus, ulcers, etc.
In recent years, triple oxygen therapy has become an increasingly widely used treatment method in clinical practice. This non-mainstream medical treatment method can replace the main methods that are limited by the dosage of pharmaceutical agents and various pathological conditions that are not suitable for conventional treatment, and it helps to stabilize the disrupted self-regulatory balance, improve the performance status of various organs and systems, and activate the self-protection ability of the organism. The use of triple oxygen therapy is very common in foreign countries. In a series of international professional conferences in recent years, including the 4th All-Russian Conference of Applied Sciences, a large amount of experimental and clinical data on the use of trioxane therapy was published and accumulated, which clearly pointed out the medical usefulness of trioxane from both sides and determined the basic methods of using trioxane, making the parameters of the original treatment methods more clear.
Its safety, clinical efficiency, good tolerance of patients during treatment, and relatively low price are all characteristics that facilitate the application of triple oxygen therapy in various medical institutions alone or in combination with other treatment methods.
VII. Contraindications of trioxane therapy
Hyperthyroidism, myocardial infarction, hypotension, hypocalcemia, hypoglycemia, internal bleeding, pregnant women, thrombocytopenia, coagulation mechanism disorder, trioxic allergy, acute ethanol poisoning, citrus allergy, etc.
Eight, the choice of the course of treatment of the clinical application of trioxin
1.Large autotransfusion treatment: 5 times for small course, 10 times for medium course, 15 times for large course
2.Small self-blood treatment: 10 times per course, once every 2 days.
3.Extracorporeal bag treatment: 10 times per course, once every 2 days.
4.Cavity gas injection therapy: 10 times per course, once every 2 days.
5.Triple ozone water therapy: 10 times per course, once a day.
6.Triple oxygen minimally invasive intervention therapy: one-time treatment.
Nine, the choice of triple oxygen treatment concentration
1.Large autologous blood treatment: starting concentration 25-30ug/ml. 5ug/ml increment each time. maximum not more than 50ug/ml.
2.Small autotransfusion therapy: starting concentration 10ug-15ug/ml. 5ug/ml increment each time.
3.Cavity gas injection: starting concentration 20ug/ml. 5ug/ml increment each time.
4.In vitro bag: starting concentration 35ug/ml, each time increment 5ug/ml.
5.Trioxane: starting concentration 35ug/ml.
6.Trioxane oil: starting concentration 15ug/ml
7.Minimally invasive intervention: 27ug-50ug/ml, choose according to the condition. Venous blood to arterial blood: 30ug/ml
Treatments of trioxane
(A) Triple oxygen therapy for ankylosing spondylitis
Ankylosing spondylitis (AS) is the most common type of SPA, with an incidence of 0.26% in our country and a higher incidence in men than in women, with a male to female ratio of 5:1. The cause of the disease has not yet been fully clarified, and most scholars believe that the development of AS is closely related to genetic and environmental factors.
Laboratory tests: no specific or marker indicators have been found. The rheumatoid factor in the serum and joint fluid is negative, but in active patients the sedimentation is increased, and the C-reflective protein is increased. 90% of patients are positive for HLA-B27. The patient’s pain is mainly limited in movement. Patients with painful activity limitation, involving the hip joint has a high disability rate, if the occurrence of cervical spine can be life-threatening.
Traditional treatment methods.
Drug therapy, non-steroidal anti-inflammatory drugs, anti-rheumatic drugs, etc. The drugs are toxic to the stomach and kidneys and have poor efficacy.
The methods of trioxane therapy are as follows.
Sacroiliac joint cavity puncture injection of trioxin, 20-40ml per side, concentration 45mg/L, once every 5 days. Each time the concentration of trioxane is increased by 5mg/L, 4 times for a course of treatment. The painful spot was also injected at the same time.
– The local injection was accompanied by an intravenous infusion of trioxane saline. The concentration was increased from 25mg/L to 5mg/L after 5 days and up to 60mg/L with 500ml of saline with 60ml of trioxane each time.
– Why is sacroiliac joint cavity injection of trioxane effective in treatment?
– Recent studies have shown that the occurrence and development of AS condition is related to the polymorphism of TNF-α gene and the up-regulation of local TNF-α expression in the serum and sacroiliac joints.
(II) Trioxane for psoriasis
Psoriasis is a common chronic recurrent inflammatory skin disease with typical lesions of scaly erythematous plaques, mostly occurring in young adults.
(Etiology) The exact cause of psoriasis is not yet clear. At present, it is thought to be related to genetic factors, environmental factors and immune factors.
Clinical manifestations: the incidence rate in China is 0.123%. Clinically, it is divided into
1.Unusual type (accounting for more than 99%)
A typical skin lesions
B bunchy hair
C Acute punctate psoriasis
2, arthritic psoriasis, in addition to skin lesions, joint involvement may occur. Individuals with no skin lesions directly present with joint damage. Pain is severe.
3.Pustular psoriasis: flaky, yellowish or yellowish-white, potentially sterile small pustules with swelling and pain. Systemic symptoms appear, with chills and high fever. Death may occur due to secondary infection and systemic failure.
Triple oxygen treatment: Four methods are used in combination.
1) Small autotransfusion therapy 1 time/3 days 10ml of venous blood is drawn from a 20ml syringe with 50mg/L concentration of ozone 10ml mixed with venous blood and injected intramuscularly, 10 times as a course of treatment.
(2) Sacroiliac joint cavity injection 1 time/3 days 20ml (60mg/L)
3) Ozone saline infusion 500ml + O3 (60ml) (25mg/L)
4) Ozone oil injected with olive oil 50ml 60mg/L O3 50ml into the refrigerator frozen 3-4 times daily for external use
Generally 3 courses of treatment patients significantly improved, the longest person 2 years without recurrence.
(C) Triple Oxygen Therapy for Prostatitis
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