Ursodeoxycholic acid can be taken orally for some autoimmune liver diseases, but it is necessary to pay attention to the detection of liver function, and it is recommended to stop using the drug in time if there are adverse reactions. Clinically, autoimmune liver disease mainly includes three types, namely autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. Primary sclerosing cholangitis and primary biliary cholangitis can be treated with ursodeoxycholic acid. However, the drug is not usually used routinely for autoimmune hepatitis. Regular testing of liver function parameters such as alanine aminotransferase (AST) and alanine aminotransferase (ALT) is recommended during the course of the medication. In case of serious adverse reactions such as intolerable diarrhea, severe hepatobiliary dysfunction, urticaria, etc., it is recommended to discontinue the use of the drug and seek prompt medical attention. Ursodeoxycholic acid is contraindicated in autoimmune liver diseases that are combined with drug hypersensitivity, acute cholecystitis, biliary obstruction, frequent biliary colic attacks, and gallbladder function impairment. Ursodeoxycholic acid needs to be used under the supervision of a clinician.