Vaccination is contraindicated in different vaccines and is generally not recommended in the following cases. For details, consult the staff at the vaccination station or hospital: 1. People who are allergic to the active or inactive components of the vaccine or the substances used in the production of the vaccine, or those who have had allergic reactions to similar vaccines, should not be vaccinated; 2. People with a history of epilepsy or convulsions. People with chronic diseases and neurological diseases are also not suitable for vaccination, and vaccination may aggravate or induce diseases; 3. People with immunodeficiency diseases are not suitable for vaccination, such as Hashimoto’s thyroiditis, systemic lupus erythematosus, leukemia, etc., where the patient’s immune system is damaged and cannot produce an antibody response, thus failing to produce sufficient protection for the organism; 4. Patients with acute diseases are not eligible for vaccination Vaccination can be carried out after the disease has subsided, such as influenza, fever, acute gastroenteritis, acute tonsillitis, etc., so as not to aggravate the uncomfortable symptoms after vaccination, cover up the disease and delay the treatment; 5. 6. If immunosuppressants, immunomodulators, glucocorticoids, human immunoglobulin, etc. have been used before vaccination, the vaccination should be temporarily stopped because the patient’s immune protection status is weak and therefore cannot produce sufficient antibodies. In addition to the above-mentioned general vaccination contraindications, some common vaccines also have special contraindications: 1. BCG vaccine: patients with eczema, purulent otitis media and serious skin diseases are not suitable for vaccination; 2. polio vaccine: patients with severe diarrhea need to suspend polio vaccination; 3. others: such as HPV vaccine and herpes zoster vaccine are recommended to be vaccinated at the prescribed age to be able to play a better role in immunization. The immunization effect is better.