Patients who are diagnosed with seronegative arthritis need to actively cooperate with their doctors. Common treatments include medication and physical therapy. 1. Medication: In the early stage of diagnosis, non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac and celecoxib, can be used to relieve pain and inflammation. However, if the disease is more serious and the above drugs have been used for several months, anti-rheumatic drugs can be used to improve the condition, such as methotrexate, salicylazosulfapyridine and hydroxychloroquine. Different drugs are suitable for different groups of people and should be used systematically under the guidance of doctors. 2. Physical therapy: the corresponding joints can be treated with physical methods such as hot compresses, massage and closure. It is recommended that patients with seronegative arthritis should consult the Rheumatology and Immunology Department in time, and actively cooperate with the doctor’s treatment, and do not blindly self-medication, so as not to delay the condition or other adverse reactions.