Nine-valent usually refers to the HPV nine-valent vaccine, at present in the domestic HPV nine-valent vaccine is suitable for vaccination age is 16 to 26 years old, for the time being does not recommend that women over the age of 26 years of age vaccination. HPV nine-valent vaccine in China is recommended for women aged 16 to 26 years to be vaccinated, mostly because the clinical trials of the domestic HPV nine-valent vaccine were conducted in the age group of 16 to 26 years old, and there is no effective argument about the effect and safety of the vaccination for women over 26 years old. Therefore, for safety reasons, the HPV 9-valent vaccine is recommended to be administered between the ages of 16 and 26, and is not recommended to be administered past the age of 26. For those over the age of 26 who are eligible for vaccination, HPV bivalent vaccine or quadrivalent vaccine is recommended, which can also have a good preventive effect against high-risk HPV infections.