Rivaroxaban can be taken for a long time. Rivaroxaban has the effect of anticoagulation, the main mechanism of action is to inhibit coagulation factor Xa, can prolong the coagulation time, clinically can be used for the treatment of thrombotic diseases, such as lower extremity venous thrombosis, non-valvular disease atrial fibrillation arterial embolism prevention. Lower extremity venous thrombosis can be treated with oral medication for a short period of time, and the medication can be discontinued when symptoms improve. For patients with non-valvular atrial fibrillation, long-term oral rivaroxaban is needed to prevent arterial embolism. Long-term oral rivaroxaban should pay attention to the adverse reactions of the drug, the main adverse reaction is bleeding, most patients for the appearance of the skin mucosa, a few patients may occur in the digestive tract, respiratory tract, cerebral hemorrhage and so on. If adverse reactions occur during the course of taking the drug, it is necessary to go to the hospital in a timely manner and be treated under the guidance of a physician.