The symptoms of hyper-IgE syndrome are: 1. Recurrent skin infections, manifested as chronic eczema, intense itching, and mossy changes over time. 2. Recurrent lung infections, which can be life-threatening. It is often complicated by bronchiectasis, pulmonary cavitation, pulmonary alveoli, pulmonary nodules, bronchopleural fistula. 3. special facial features, facial skin roughness, widening of the nose and nasal bridge, protrusion of the forehead, widening of the eye spacing. 4. abnormalities of the skeletal system, double rows of teeth can be formed if the milk teeth do not fall out, joint hyperextension, scoliosis, osteoporosis, and often recurrent fractures. 5. other symptoms, chronic Candida infection of the mucous membranes and nails, and abnormalities of the blood vessels of the nervous system, etc.