When performing a thyroid puncture biopsy, risks such as bleeding, hematoma, and infection may occur. People are advised to perform the operation in regular hospitals to avoid damage to the human body due to improper operation. 1. Bleeding or hematoma: Thyroid puncture biopsy is an invasive operation, which can lead to local bleeding when it touches the blood vessels around the thyroid swelling during the operation, and hematoma is formed in case of serious bleeding. 2. Infection: improper operation may lead to patient infection, including bacterial, viral, fungal and other pathogenic microorganisms infection. Therefore, the operator of thyroid puncture should strictly execute aseptic operation to reduce the risk of infection. Infected patients can be treated with medications under the supervision of a physician. Thyroid puncture biopsy is recommended to be operated in regular hospitals.