Lung squamous carcinoma usually does not have gene mutation after treatment, which may be caused by genetic mutation, mutation of DNA molecules in genetic organization. If squamous lung cancer can be effectively treated and controlled in the early stage, gene mutation usually will not occur. When this happens, patients can adopt targeted therapy to effectively control the disease. Gene mutation in squamous lung cancer may be caused by genetic mutation or sudden appearance of DNA molecules in genetic organization. Under some specific conditions, genes may suddenly change from their original form of existence, to another new form of existence. At this time the existing gene will replace the original gene, thus creating a situation of gene mutation. Clinically, gene mutation in squamous lung cancer may also be caused by smoking, air pollution, occupational factors and so on. Patients should consult the doctor in time and choose targeted treatment to clarify the cause of the disease.