The first category, Botox allergy candidates must not fight. In the botulinum toxin injection must be done before the skin test, if itself is allergic to the body more then to pay attention to its life for fish and shrimp and other food allergies must be informed to the doctor. The second category, too young. For example, one or two-year-old babies can not be injected Botox wrinkle, usually before the age of 12 are not recommended to inject Botox. In the third category, breastfeeding women or pregnant women can not be injected. If there are neurological diseases, such as myasthenia gravis patients, also can not be injected. The fourth category, local infection or bleeding disease candidates can not be injected. For the people who can not be injected, it is probably such a range. Another thing to note is that Botox must be injected by a doctor in a hospital, beauty salons or non-medical institutions can not be injected. Our country is very strict on the injection of drugs, each drug is required to do traceability. Which pharmaceutical company you imported from, in which hospital for injection, requires the whole traceability. When I go to other hospitals as a medical beauty quality control expert in Shaanxi Province, I focus on auditing the Botox’s, hyaluronic acid and other drugs. For botulinum toxin is domestic good or imported good, in fact, fundamentally speaking, both are the same kind of substance. Only in the purity of the drug and purification methods have some differences, but the overall difference is not big. If you are in limited financial condition, try to choose domestic Botox, if you are in generous financial condition, there is nothing wrong to choose imported Botox. From my personal experience, I tend to recommend domestic botulinum toxin if you are choosing a wide range of injections, such as slimming legs and shoulders. But for fine injections on the face, imported ones with less dispersion are more recommended. From a clinical point of view, there is indeed a difference between the two, but given that the price of imported botulinum toxin is one or two times higher than that of domestically produced, domestically produced is better in terms of cost-effectiveness. What I can tell you is that I personally injected is domestic, played for many years the effect is also good. Some beauty seekers are afraid that Botox injections will not be “addictive”, and if they stop injecting, will they “rebound”. This situation will not occur, Botox is a temporary effect, tube half a year or so. After the effect of the drug wears off, the wrinkles will slowly appear again.