The application of antihypertensive drugs should follow the principle of individualization, under the guidance of physicians, and there is no such thing as taking a certain drug for the first time is better. Clinical antihypertensive drugs include diuretics, β-receptor antagonists, calcium channel blockers and other five types. The application of antihypertensive drugs should follow the following principles: start with small doses, give priority to long-acting agents, combine drugs and individualization. Among them, the principle of individualization is particularly important in the drug treatment of hypertensive patients, and the drug regimen of each individual may differ. Therefore there is no such thing as which antihypertensive drug is better to take for the first time. Doctors need to choose the right antihypertensive drug according to the patient’s specific situation, drug effectiveness and tolerability, taking into account the patient’s financial conditions and personal wishes. Each drug has a different mechanism of action and should be chosen according to the patient’s specific condition. Therefore, when suffering from high blood pressure need to go to the hospital for standardized diagnosis and treatment, follow the doctor’s instructions to take medication, avoid unauthorized use of drugs.