I. Drugs that should be discontinued before pregnancy 1. Methotrexate: discontinue 3 months before pregnancy and prohibit during pregnancy. After stopping methotrexate, at least wait for the next menstrual period to consider pregnancy, and it is recommended to supplement folic acid before and during pregnancy. 2. Leflunomide: discontinue 2 years before planned pregnancy. For unintended pregnancy before planned pregnancy or during treatment, rapid cleansing of active metabolites of leflunomide can be performed with anticholinergic amines. 3, Rituximab (Merova): a human-mouse chimeric monoclonal antibody targeting the CD20 antigen expressed on mature B cells and B cell precursors. Discontinue use 1 year before planned pregnancy. 4, Abatacept (Abatacept): is a selective T-cell co-stimulatory regulator, can block the key signals of T-cell activation co-stimulatory pathway, inhibit and reverse the inflammatory process. Discontinue use 10 weeks before planned pregnancy. Second, the drugs should be discontinued in pregnancy 1, anti-TNF biologics (class grams, Isapro, adalimumab): it is not clear whether the TNF antagonist treatment has a long-term effect on the fetus, once it is determined that the pregnancy has been discontinued immediately. 2. Bisphosphonates (Fosamax, Guibang, etc.): Intravenous bisphosphonates can cause fetal hypocalcemia and should be used with caution during pregnancy. Since there is no follow-up on the long-term effects on the infant, any type of bisphosphonate should be discontinued once pregnancy occurs. C. Drugs available in pregnancy 1. Chloroquine phosphate and hydroxychloroquine: are safe for the fetus. Since the number of cases observed with hydroxychloroquine during pregnancy is more than that of chloroquine phosphate, and the concentration in maternal tissues is lower in the former than in the latter, hydroxychloroquine during pregnancy is better than chloroquine phosphate. 2.Liuazasulfapyridine: can be used in pregnancy, but need to supplement folic acid. 3.Azathioprine:can be used in pregnancy, but the dose should be less than 2mg/kg.d. If the dose is high, there is a risk of fetal erythropoiesis inhibition. 4.Cyclosporin A:Cyclosporin can be taken during pregnancy at a dose of 2.5-5.0 mg/kg.d. 5.Hormones:You can take oral prednisone or intra-articular injection of hormones. However, they should be given in the smallest dose during the first 3 months of pregnancy (to avoid increasing the risk of orofacial clefts). Long-term hormone users need to appropriately increase the dose in the perinatal period. 6, non-steroidal anti-inflammatory drugs: the first 32 weeks of pregnancy, give priority to the use of drugs with a short half-life, such as lexapro. The use of such drugs should be discontinued after 7 months of pregnancy. It is best to take the lowest effective dose of non-steroidal anti-inflammatory drugs intermittently to reduce the risk of adverse fetal reactions. IV. Treatment options for exacerbations in pregnancy Acute arthritis flares during pregnancy can occur in 10-25% of patients. Available methods are as follows: 1, more than one arthritis: can be intra-articular injection of hormones, at the same time oral non-steroidal anti-inflammatory drugs (including Fitalin, ibuprofen, naproxen, etc.), should be noted that 32 weeks of pregnancy should be discontinued. 2.Only arthralgia: paracetamol can be used, 1-4g/day is a safe dose. 3.Systemic symptoms: oral small doses of hormones, while adjusting the second-line drug therapy.