Tramadol is a commonly used pain medication, which can be applied to pain relief treatment during perioperative period or advanced tumor stage, belongs to opioid pain medication, and also has many side effects. The most common is gastrointestinal irritation symptoms after taking the drug, patients will have epigastric pain, so it is best to give the patient some food before taking the drug, including milk or fruit juice. In addition, due to the side effects of opioids, the commonality is to inhibit intestinal peristalsis, so many patients will appear habitual constipation after the use of medication, can give oral phenolphthalein tablets or oral senna brewed water to play the role of laxative, and painkillers can be spaced out the use of to reduce the incidence of its side effects, can be combined with diazepam injections to play a role in local sedation as well as analgesic.