Poor handgrip reflexes in newborns may be a normal physiological phenomenon, or it may be caused by cerebral palsy. 1. Normal physiological phenomenon: poor handgrip reflexes may occur in newborns due to the immature development of the brain’s nervous system and the relatively weak innervation of the limbs. 2. Cerebral palsy: It is usually caused by brain damage due to birth injury, preterm birth, lack of oxygen, etc., which can lead to postural abnormality and motor disorders, and thus may show poor handgrip reflexes, and may be accompanied by speech disorders, mental retardation, and abnormal muscle tone. Poor handgrip reflexes in newborns may also be caused by other reasons. If the symptoms persist and cannot be relieved, or if there are other discomforts, medical attention should be sought as soon as possible, and targeted treatment should be given after confirming the causative factors.