The difference between urine sugar 3+ and urine protein + is that they represent different clinical significance. However, there are some diabetic patients with the above situation, indicating the possible existence of diabetic nephropathy. 1. Urine sugar 3+: indicates positive urine sugar, which can be seen in diabetes mellitus, stress diabetes (such as craniocerebral trauma, cerebrovascular accident, emotional excitement and other conditions), intake diabetes (intake of large amounts of sugar within a short period of time or infusion of hypertonic glucose solution), renal glycosuria (see chronic nephritis, nephrotic syndrome, interstitial nephritis, familial diabetes mellitus, etc.). 2. Urine protein +: including physiological proteinuria (such as functional proteinuria, postural proteinuria) and pathological proteinuria (such as acute nephritis, renal ischemia and diabetic nephropathy; pyelonephritis, interstitial nephritis, etc.). It is recommended that patients with abnormal urine routine should go to the relevant departments of the hospital in time, and under the guidance of professional doctors, improve the relevant examinations, so as to clarify the diagnosis and receive standardized treatment.