Second ejaculation may be caused by physiological factors such as mental stress and physical exertion; it may also be caused by diseases such as premature ejaculation, prostatitis and prostate hyperplasia. According to the different causes, patients can follow the doctor’s instructions to choose the appropriate way of treatment, such as general treatment, medication and so on. 1. Physiological factors: If the second ejaculation is caused by mental stress, physical fatigue, prolonged sexual repression, etc., there is no need for special treatment, adjust the physical and mental state can be. Do not have too much mental pressure during intercourse, usually maintain a regular frequency of intercourse, such as one to three times a week. 2. Premature ejaculation: If the premature ejaculation leads to a second ejaculation, the patient can follow the doctor’s instructions to take dapoxetine, fluoxetine and other 5-hydroxytryptamine reuptake inhibitors class of drugs to improve the premature ejaculation symptoms. 3. Prostatitis: If prostatitis causes ejaculation, the patient should do a good job of private hygiene care, follow the doctor’s prescription oral quinolone drugs, such as Moxifloxacin, Gatifloxacin, etc., to play an anti-inflammatory effect. 4. Prostatic hyperplasia: If the prostatic hyperplasia leads to ejaculation, the patient can follow the doctor’s prescription oral α1-blocker drugs, such as doxazosin, terazosin, tamsulosin, etc., to achieve the effect of relaxation of urethral smooth muscle. It is recommended that patients with second ejaculation exclude physiological factors, go to the hospital for relevant examination, clear cause of the disease, and then follow the doctor’s instructions to treat the cause of the disease.