Pregnancy after three months of MTX withdrawal does not cause fetal malformations.
MTX is an antifolate metabolizing drug with strong immunosuppressive effect. It can selectively act on proliferating cells, preventing the division and proliferation of immunoblasts, inhibiting both humoral and cellular immunity, with strong anti-inflammatory effects, and is most often used in the treatment of rheumatoid arthritis.
MTX has embryotoxicity and teratogenicity, can be used in the treatment of ectopic pregnancy embryocidal treatment, in pregnancy and lactation should not be used. However, MTX can be completely metabolized within 2 weeks, therefore, pregnancy after 3 months of MTX withdrawal will not result in fetal malformations, and preparation for pregnancy should be carried out under the guidance of a doctor.