Acipimox has a decreasing effect on lipoprotein a. Apolipoprotein a is a transport protein in the body, which has a contributing role in the development and progression of atherosclerosis, and elevated lipoprotein a increases the incidence of cardiovascular and cerebrovascular events. 1. Acipimox is a derivative of nicotinic acid, which can lower triglyceride and cholesterol levels, and also has a lowering effect on lipoprotein A and an elevating effect on HDL. 2. The adverse reactions of Acipimox include headache, gastrointestinal burning sensation, abdominal pain, flushing, skin itching, etc. Symptoms are obvious at the early stage of taking the drug, and can be gradually relieved in some patients. Allergic to the components of the drug, lactating pregnant women, active peptic ulcer patients are prohibited. The use of acipimox needs to follow the doctor’s instructions, not unauthorized use of drugs, so as not to cause adverse consequences.